| 溶解性 | DMSO 67 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Plinabulin (NPI-2358)是一种vascular disrupting agents(VDA)（血管阻断剂），作用于肿瘤细胞，影响微管蛋白解聚，IC50为9.8~18 nM。Phase 1/2。 |
| 备注 | Plinabulin (NPI-2358) is a vascular disrupting agents (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 2. |
| 生化机理 | NPI-2358 (Plinabulin) is a novel vascular disrupting agent (VDA) with an IC50 of 15 nM against HT-29 cells. NPI-2358 binds to the colchicine-binding site of tubulin. NPI-2358 has potent in-vitro anti-tumor activity against various human tumor cell lines and maintains activity against tumor cell lines with various MDR profiles. |
| 别名 | (3Z,6Z)-3-benzylidene-6-((5-tert-butyl-1H-imidazol-4-yl)methylene)piperazine-2,5-dione;(3Z,6Z)-3-benzylidene-6-((5-tert-butyl-1H-imidazol-4-yl)methylene)piperazine-2,5-dione |
Plinabulin (NPI-2358)，血管阻断剂
Plinabulin (NPI-2358) （订货以英文为准）
编号：P126141
CAS号：714272-27-2
分子式：C19H20N4O2
分子量：336.39
| 产品名称 | Plinabulin (NPI-2358) |
| 中文名称 | Plinabulin (NPI-2358)，血管阻断剂 |
| CAS号 | 714272-27-2 |
| 分子式（M.F.） | C19H20N4O2 |
| 分子量（M.W.） | 336.39 |
| 储存条件 | -20°C储存 |
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