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SD-208,ATP竞争性TGF-βRI抑制剂

SD-208 （订货以英文为准）

编号：S125587
CAS号：627536-09-8
分子式：C17H10CLFN6
分子量：352.75
货号 品牌 包装 目录价 您的价格 库存 数量 购买
S125587-25mg 阿拉丁 25mg ¥515.90
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S125587-100mg 阿拉丁 100mg ¥764.90
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S125587-5mg 阿拉丁 5mg ¥308.90
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产品名称 SD-208
中文名称 SD-208,ATP竞争性TGF-βRI抑制剂
CAS号 627536-09-8
MDL编码 MFCD11519969
分子式（M.F.） C17H10CLFN6
分子量（M.W.） 352.75
储存条件 -20°C储存
沸点460.41° C at 760 mmHg
熔点214.79° C
折光率1.72
溶解性DMSO >10 mg/mL
存贮条件储存温度-20°C
密度1.4900
应用A TGF-β signaling blocker
产品介绍SD-208是口服活性的ATP竞争性TGF-βRI抑制剂，IC50为49 nM，比对TGF-βRII和其它激酶的抑制性高100倍和17倍。
生化机理SD-208 is a potent, orally active TGF-βR I kinase inhibitor (TGF-βRI) with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII. SD-208 exhibits anti-inflammatory and antitumor activity.
别名SD 208; SD208; SCI 208; 2-(5-氯-2-氟苯基)-N-4-吡啶基-4-蝶啶胺;SD 208; SD208; SCI 208; 2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine;2-(5-Chloro-2-fluorophenyl)pteridin-4-yl)pyridin-4-yl amine
标识符号https://www.aladdin-e.com/images/ghs/ghs02.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg,https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Danger
危害声明H225,H350,H340,H304,H319,H315,H372
警示性声明P210,P201,P308+P313,P301+P330+P331,P305+P351+P338,P314
个人防护设备Faceshields,full-face respirator (US),Gloves,Goggles,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter
WGK德国3
风险声明 (欧洲)45,46,11,36/38,48/23/24/25,65
安全声明（欧洲）53,26,36/37,45,62
危害码（欧洲）F,T
是否危化品一般危化品
UN代码3462
搜索质检报告(COA)
搜索MSDS
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