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欧前胡素

Imperatorin （订货以英文为准）

编号：I114064
CAS号：482-44-0
分子式：C16H14O4
分子量：270.28
货号 品牌 包装 目录价 您的价格 库存 数量 购买
I114064-250mg 阿拉丁 250mg ¥703.90
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I114064-25mg 阿拉丁 25mg ¥161.90
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I114064-100mg 阿拉丁 100mg ¥470.90
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I114064-1g 阿拉丁 1g ¥1767.90
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产品名称 Imperatorin
中文名称 欧前胡素
CAS号 482-44-0
分子式（M.F.） C16H14O4
分子量（M.W.） 270.28
储存条件 -20°C储存
溶解性Soluble in DMSO (≥5 mg/ml), methanol, DMF, and water (slightly). Insoluble in ethanol.
存贮条件储存温度2-8°C
密度1.2420
产品介绍属呋喃香豆素类化合物。为棱柱状结晶（由乙醚）、长细针晶（由热水），易溶于氯仿，可溶于苯、乙醇、乙醚和苛性碱溶液，不溶于冷水。Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.
生化机理欧前胡素是p38、ERK路径的调控因子。欧前胡素增加BMP-2的表达(mRNA) ,体外研究证实欧前胡素增加体内骨质密度/体积和矿物化。
别名欧前胡素;8-Isopentenyloxypsoralen;9-(3-Methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-one;9-[(3-Methyl-2-buten-1-yl)oxy]-7h-furo[3,2-g][1]benzopyran-7-one;AmmidinMarmelideMarmelosinNSC 402949
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