| 溶解性 | Soluble in ethanol (100 mM), DMSO (40 mg/ml), DMF (~15 mg/ml), and Ethanol : PBS (1:1) (~0.5 mg/ml) |
| 存贮条件 | 储存温度2-8°C |
| 应用 | An aminophenylpropanoate agonist at the GRP40/FFA1 receptor. |
| 产品介绍 | GW9508是一种有效的，选择性FFA1(GPR40)激动剂，pEC50为7.32，比作用于GPR120选择性高100倍，以葡萄糖敏感性方式刺激胰岛素的分泌。 |
| 备注 | GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner. |
| 生化机理 | GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ～50 nM) with reduced activity towards family members GRP120 (EC50 ～3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors. GW 9508 has been shown to induce GPR40-dependent Ca2+ mobilization in HEK 293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. |
| 别名 | 4-[[(3-苯氧基苯基)甲基]氨基]苯丙酸;GW 9508;GW-9508;3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid; GPR40 Agonist;4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid |
GW9508,FFA 1受体激动剂
GW9508 （订货以英文为准）
编号：G126253
CAS号：885101-89-3
分子式：C22H21NO3
分子量：347.41
| 产品名称 | GW9508 |
| 中文名称 | GW9508,FFA 1受体激动剂 |
| CAS号 | 885101-89-3 |
| MDL编码 | MFCD09753282 |
| 分子式（M.F.） | C22H21NO3 |
| 分子量（M.W.） | 347.41 |
| 储存条件 | 2-8°C储存 |
| Merck Index | 3708 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H350,H360 |
| 警示性声明 | P201,P308+P313 |
| 个人防护设备 | Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges |
| RTECS | KG8575000 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | 45,60,61 |
| 安全声明（欧洲） | 53,45 |
| 危害码（欧洲） | T |
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