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PJ34 盐酸

PJ34 HCl （订货以英文为准）

编号：P129886
CAS号：344458-15-7
分子式：C17H18CLN3O2
分子量：331.80
货号 品牌 包装 目录价 您的价格 库存 数量 购买
P129886-5mg 阿拉丁 5mg ¥227.90
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P129886-25mg 阿拉丁 25mg ¥369.90
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P129886-100mg 阿拉丁 100mg ¥1010.90
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P129886-1mg 1mg ¥56.90
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产品名称 PJ34 HCl
中文名称 PJ34 盐酸
CAS号 344458-15-7
分子式（M.F.） C17H18CLN3O2
分子量（M.W.） 331.80
储存条件 -20°C储存
溶解性DMSO 66 mg/mL Water 66 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
产品介绍PJ34 HCl 是PJ34的盐酸盐形式，是一种PARP抑制剂，EC50为20 nM，同等有效作用于PARP1/2。
备注PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
生化机理PARP Inhibitor VIII, PJ34 is a cell-permeable, water-soluble phenanthridinone derivative which inhibits of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). It is believed to be up to 10,000 times more potent than 3-aminobenzamide which has an EC = 200 μM. Studies have shown that PARP over-activation can lead to NAD depletion and consequent necrosis, thus inducing inflammatory conditions in many diseases. It has been observed that at lower concentrations, PARP Inhibitor VIII, PJ34 displays antioxidant activity. Studies conducted in vitro on stroke models indicate that this compound has neuroprotective functions. PARP Inhibitor VIII, PJ34 is an inhibitor of PARP-1 and PARP-2.
别名PJ 34 盐酸盐; N-(6-氧代-5,6-二氢菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺盐酸盐;PJ-34 hydrochloride; PJ 34 hydrochloride;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride;2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride
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