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RO4929097

RO4929097 （订货以英文为准）

编号：R127403
CAS号：847925-91-1
分子式：C22H20F5N3O3
分子量：469.40
货号 品牌 包装 目录价 您的价格 库存 数量 购买
R127403-50mg 阿拉丁 50mg ¥1439.90
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R127403-5mg 阿拉丁 5mg ¥317.90
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R127403-10mg 阿拉丁 10mg ¥377.90
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R127403-1mg 阿拉丁 1mg ¥500.00
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R127403-25mg 阿拉丁 25mg ¥762.90
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产品名称 RO4929097
中文名称 RO4929097
CAS号 847925-91-1
分子式（M.F.） C22H20F5N3O3
分子量（M.W.） 469.40
储存条件 -20°C储存
溶解性DMSO 94 mg/mL Water <1 mg/mL Ethanol 16 mg/mL
存贮条件储存温度-20°C
备注RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.
生化机理RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. It binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. This leads to reduced expression of the Notch transcriptional target gene Hes 1. RO4929097 does not block tumor cell proliferation or induce apoptosis but instead produces a less transformed, flattened, slower-growing phenotype.
别名Propanediamide, N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)-;Propanediamide, N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)-
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