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Nutlin-3,MDM2拮抗剂

Nutlin-3 （订货以英文为准）

编号：N126055
CAS号：548472-68-0
分子式：C30H30CL2N4O4
分子量：581.49
货号 品牌 包装 目录价 您的价格 库存 数量 购买
N126055-10mg 阿拉丁 10mg ¥1183.90
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N126055-100mg 阿拉丁 100mg ¥6169.90
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N126055-50mg 阿拉丁 50mg ¥3704.90
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产品名称 Nutlin-3
中文名称 Nutlin-3,MDM2拮抗剂
CAS号 548472-68-0
MDL编码 MFCD07784509
分子式（M.F.） C30H30CL2N4O4
分子量（M.W.） 581.49
储存条件 -20°C储存
溶解性Soluble in ethanol (25 mg/ml), DMSO (20 mg/ml), DMF, methanol, and acetonitrile. Insoluble in water. Sparingly soluble in ethanol:PBS pH 7.2 (1:10).
存贮条件储存温度-20°C
应用Disrupts MDM2-p53 interaction, inducing apoptosis.
产品介绍Nutlin-3是一种有效的，选择性的Mdm2(依赖环指状的泛素蛋白连接酶和p53)拮抗剂，IC50为90 nM。可稳定p53缺陷的细胞中的p73。
生化机理Nutlin-3, the racemic and most commonly used form of nutlin, inhibits p53-MDM2 interaction. It has shown ability to induce the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. When in combination with perifosine, anti-leukaemic activity has been observed. High N-MYC (MycN) expression has been induced in non-N-MYC-amplified neuroblastoma cells when treated with the combination of nutlin-3 and doxorubicin
别名4-[4,5-双(4-氯苯基)-2-(4-甲氧基-2-异丙氧基苯基)-4,5-二氢咪唑-1-羰基]哌嗪-2-酮;Nutlin 3;Nutlin3;4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one;
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