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(±)-吴茱萸碱

(±)-Evodiamine （订货以英文为准）

编号：E140884
CAS号：518-18-3
分子式：C19H20N3O2BR
分子量：303.36
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E140884-25g 阿拉丁 25g ¥1852.90
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E140884-5g 阿拉丁 5g ¥587.90
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E140884-1g 阿拉丁 1g ¥175.90
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产品名称 (±)-Evodiamine
中文名称 (±)-吴茱萸碱
CAS号 518-18-3
分子式（M.F.） C19H20N3O2BR
分子量（M.W.） 303.36
储存条件 2-8°C储存
熔点278°C
敏感性对光敏感
溶解性Soluble in DMSO (5 mg/mL,warm to 40°C), water (<1 mg/mL) at 25 °C, and ethanol (<1 mg/mL) at 25 °C
存贮条件储存温度2-8℃
应用An antiangiogenic and antiinflammatory agonist of TRPV1.
产品介绍Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin .Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine .Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects.
生化机理The interferon-γ priming signal regulating the transcriptional activation of the iNOS gene is blocked by Evodiamine, suppressing iNOS protein synthesis but not affecting iNOS function. Evodiamine also demonstrates antiangiogenesis through inhibition of vascular endothelial growth factor gene expression and inhibition of the ERK 1 (p44)/ERK 2 (p42) mitogen-activated protein kinase that correlated to endothelial cell angiogenesis. Promotion of apoptosis in human leukemic U937 cells is described with Evodiamine.
别名吴茱萸胺;
个人防护设备Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECSFW6420000
WGK德国3
安全声明（欧洲）S22;S24/25;
搜索质检报告(COA)
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