| 溶解性 | DMSO 83 mg/mL Water 100 mg/mL Ethanol 24 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | LY2835219对CDK4和CDK6的IC50分别为2 nM和10 nM。 |
| 生化机理 | LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. CDK4/6 dual inhibitor LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. |
| 别名 | LY2835219；LY 2835219;LY-2835219；N-[5-[(4-乙基-1-哌嗪基)甲基]-2-吡啶基]-5-氟-4-[4-氟-2-甲基-1-异丙基-1H-苯并咪唑-6-基]-2-嘧啶胺甲烷磺酸盐;CDK4/6 dual inhibitor;LY 2835219;LY-2835219；N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine methanesulfonate (1:1) |
Abemaciclib (LY2835219)
Abemaciclib (LY2835219) （订货以英文为准）
编号：L124851
CAS号：1231930-82-7
分子式：C27H32N8F2.CH4O3S
分子量：602.70
| 产品名称 | Abemaciclib (LY2835219) |
| 中文名称 | Abemaciclib (LY2835219) |
| CAS号 | 1231930-82-7 |
| 分子式（M.F.） | C27H32N8F2.CH4O3S |
| 分子量（M.W.） | 602.70 |
| 储存条件 | -20°C储存 |
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