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ML133 盐酸盐

ML133 HCl （订货以英文为准）

编号：M129577
CAS号：1222781-70-5
分子式：C19H19NO.HCL
分子量：313.82
货号 品牌 包装 目录价 您的价格 库存 数量 购买
M129577-10mg 阿拉丁 10mg ¥171.90
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M129577-50mg 阿拉丁 50mg ¥617.90
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M129577-5mg 阿拉丁 5mg ¥114.90
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M129577-250mg 阿拉丁 250mg ¥592.90
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M129577-1g 阿拉丁 1g ¥1215.90
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产品名称 ML133 HCl
中文名称 ML133 盐酸盐
CAS号 1222781-70-5
MDL编码 MFCD20921521
分子式（M.F.） C19H19NO.HCL
分子量（M.W.） 313.82
储存条件 2-8°C储存
溶解性DMSO 63 mg/mL Water <1 mg/mL Ethanol 6 mg/mL
存贮条件储存温度 2-8°C
应用ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.
产品介绍ML133 HCl是一种选择性钾离子通道抑制剂，作用于Kir2.1， IC50为1.8 μM (pH 7.4)和290 nM (pH 8.5)，对Kir1.1没有作用效果，对Kir4.1和Kir7.1具有微弱的作用活性。
备注ML133 is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.
生化机理ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.
别名(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐;1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride; CID 781301 hydrochloride; N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride; SID 85281105 hydrochloride; VU0404943-1 hydrchloride
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