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IWP-2,PORCN抑制剂

IWP-2 （订货以英文为准）

编号：I126927
CAS号：686770-61-6
分子式：C22H18N4O2S3
分子量：466.60
货号 品牌 包装 目录价 您的价格 库存 数量 购买
I126927-50mg 阿拉丁 50mg ¥2104.90
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I126927-10mg 阿拉丁 10mg ¥648.90
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I126927-25mg 阿拉丁 25mg ¥1315.90
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I126927-100mg 阿拉丁 100mg ¥3706.90
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I126927-5mg 阿拉丁 5mg ¥360.90
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产品名称 IWP-2
中文名称 IWP-2,PORCN抑制剂
CAS号 686770-61-6
分子式（M.F.） C22H18N4O2S3
分子量（M.W.） 466.60
储存条件 -20°C储存
沸点723.12° C
熔点316.82° C
溶解性DMSO mg/mL Water mg/mL Ethanol mg/mL
存贮条件储存温度2-8℃
应用An inhibitor of Wnt production
产品介绍IWP-2 是Porcn功能钝化剂，IC50为27 nM，是Wnt生成抑制剂。
生化机理IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. Wnt/b-catenin (‘canonical’) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWP-2 inhibits Wnt production. It appears that IWP inactivates Porcn function either by directly inhibiting the Porcn active site or by modulating the function of a Porcn regulator. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. IWP-2 is useful in both regenerative medicine and anticancer efforts.
别名IWP 2; N-(6-甲基-2-苯并噻唑基)-2-((3,4,6,7-四氢-4-氧代-3-苯基噻吩并(3,2d)嘧啶-2-基)硫基)乙酰胺;;IWP 2; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
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