| 溶解性 | DMSO 72 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC. |
| 备注 | RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC. |
| 生化机理 | RGFP966 is a selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 80 nM and no inhibition of any other HDACs at concentrations up to 15 μM. In mouse studies, RGFP966 facilitated extinction of cocaine-seeking behavior and enhanced long-term object memory acquisition and consolidation. In a rat study, RGFP966 ameliorated amyloid-β oligomer-induced synaptic plasticity impairment. RGFP966 was also found to reduce proliferation and inducd differentiation in mouse lymphoid and myeloid malignancies. |
| 别名 | RGFP 966;RGFP 966; (2E)-N-(2-Amino-4-fluorophenyl)-3-[(2E)-1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide ;(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide |
RGFP966,HDAC3抑制剂
RGFP966 （订货以英文为准）
编号：R129686
CAS号：1396841-57-8
分子式：C21H19FN4O
分子量：362.40
| 产品名称 | RGFP966 |
| 中文名称 | RGFP966,HDAC3抑制剂 |
| CAS号 | 1396841-57-8 |
| 分子式（M.F.） | C21H19FN4O |
| 分子量（M.W.） | 362.40 |
| 储存条件 | -20°C储存 |
| 个人防护设备 | dust mask type N95 (US)， Eyeshields， Gloves |
| RTECS | QL6150000 |
| WGK德国 | 3 |
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