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ABT-199 (GDC-0199),Bcl-2抑制剂

ABT-199 (GDC-0199) （订货以英文为准）

编号：A124869
CAS号：1257044-40-8
分子式：C45H50CLN7O7S
分子量：868.44
货号 品牌 包装 目录价 您的价格 库存 数量 购买
A124869-100mg 阿拉丁 100mg ¥745.90
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A124869-25mg 阿拉丁 25mg ¥245.90
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A124869-5mg 阿拉丁 5mg ¥153.90
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A124869-10mg 阿拉丁 10mg ¥183.90
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A124869-50mg 阿拉丁 50mg ¥494.90
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A124869-500mg 阿拉丁 500mg ¥1853.90
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产品名称 ABT-199 (GDC-0199)
中文名称 ABT-199 (GDC-0199),Bcl-2抑制剂
CAS号 1257044-40-8
分子式（M.F.） C45H50CLN7O7S
分子量（M.W.） 868.44
储存条件 避光;-20°C储存
折光率1.64
溶解性Soluble in DMSO (100 mg/ml (~115mM) at 25 °C), water (<1 mg/ml (< 1mM) at 25 °C), and ethanol (<1 mg/ml (< 1mM) at 25 °C).
存贮条件储存温度-20°C
应用A Bcl-2-selective inhibitor with Ki of <0.01 nM
产品介绍ABT-199 (GDC-0199)是高效的Bcl-2选择性抑制剂，Ki为0.01 nM，比对Bcl-xL和Bcl-w的抑制性高4800倍以上，对Mcl-1无活性。
备注ABT-199 (GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Phase 2.
生化机理ABT-199 is a potent and selective inhibitor of B-cell lymphoma-2 (BCL-2) family proteins, currently in clinical trials. ABT-199 inhibits the growth of BCL-2-dependent tumors in vivo and spares human platelets. A single dose of ABT-199 in three patients with refractory chronic lymphocytic leukemia resulted in tumor lysis within 24 h. These data indicate that selective pharmacological inhibition of BCL-2 shows promise for the treatment of BCL-2-dependent hematological cancers.
别名GDC-0199;GDC-0199;ABT199;ABT 199;GDC0199;GDC 0199;Venetoclax ; abt 199;4-(4-((2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-n-((3-nitro-4-(((tetrahydro-2h-pyran-4-yl)methyl)amino)phenyl)sulfonyl)-2-(1h-pyrrolo(2,3-b)pyridin-5-yloxy)-benzamide
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