| 溶解性 | DMSO 79mg/mL; Water <1 mg/mL; Ethanol 31 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | AZD2461是新型PARP抑制剂，能够避免由Pgp介导的olaparib抗性。 |
| 备注 | AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1. |
| 生化机理 | AZD2461 has an 80-fold increased Mdr1b expression on Olaparib-resistant KB1P tumor T6-28, without inhibition of Pgp. AZD2461 induces loss of 53BP1 expression in mice with KB1P tumors with short-term treatment. Long-term AZD2461 treatment is well tolerated and doubled the median relapse-free survival. |
| 别名 | 4-(4-氟-3-((4-甲氧基哌啶-1-基)羰基)苄基)酞嗪-1(2H)-酮;AZD2461;AZD 2461;4-(4-fluoro-3-((4-methoxypiperidin-1-yl)carbonyl)benzyl)phthalazin-1(2h)-one |
AZD2461,PARP抑制剂
AZD2461 （订货以英文为准）
编号：A127274
CAS号：1174043-16-3
分子式：C22H22FN3O3
分子量：395.43
| 产品名称 | AZD2461 |
| 中文名称 | AZD2461,PARP抑制剂 |
| CAS号 | 1174043-16-3 |
| 分子式（M.F.） | C22H22FN3O3 |
| 分子量（M.W.） | 395.43 |
| 储存条件 | -20°C储存 |
搜索质检报告(COA)
搜索MSDS
相关产品
¥ 950.00
sh113-100m
¥ 450.00
2120A-50U
¥ 11.00
jx112303-100张
¥ 210.00
jx120423
党沛 
