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AG-1024,IGF-1受体抑制剂

AG-1024 （订货以英文为准）

编号：A126115
CAS号：65678-07-1
分子式：C14H13BRN2O
分子量：305.17
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A126115-5mg 阿拉丁 5mg ¥500.90
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A126115-25mg 阿拉丁 25mg ¥989.90
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A126115-100mg 阿拉丁 100mg ¥3460.90
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产品名称 AG-1024
中文名称 AG-1024,IGF-1受体抑制剂
CAS号 65678-07-1
分子式（M.F.） C14H13BRN2O
分子量（M.W.） 305.17
储存条件 -20°C储存
溶解性DMSO 61 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
产品介绍AG-1024 (Tyrphostin)能抑制IGF-1R自磷酸化，IC50为7 μM，而对IR的IC50则为57 μM。
备注AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins).
生化机理AG1024 (Tyrphostin AG 1024), one selective inhibitor of IGF-1R, was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. AG1024 inhibited the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and restored pRb tumor suppressive function. Human breast cancer cell studies report AG1024 to induce apoptosis, inhibit cell proliferation, decrease bcl-2 and phospho-Akt1 expression, and elevate the expression levels of Bax, p53 and p21. Studies report AG1024 to block tyrosine kinase activity and to have a lower IC50 for IGF-1 in comparison to insulin receptors. Other studies indicate that exposure of SHR cells to AG1024 decreases Ang II-mediated NAD(P)H oxidase activation.
别名HY-10253; AG 1024; AGS 200;Tyrphostin AG 1024;2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile
个人防护设备Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECSDJ3093000
WGK德国3
安全声明（欧洲）22,24/25
搜索质检报告(COA)
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