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MG-132,可逆蛋白酶体抑制剂

MG-132 （订货以英文为准）

编号：M126521
CAS号：133407-82-6
分子式：C26H41N3O5
分子量：475.62
货号 品牌 包装 目录价 您的价格 库存 数量 购买
M126521-100mg 阿拉丁 100mg ¥1360.90
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M126521-25mg 阿拉丁 25mg ¥521.90
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M126521-5mg 阿拉丁 5mg ¥175.90
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M126521-1g 阿拉丁 1g ¥5684.90
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M126521-500mg 阿拉丁 500mg ¥3706.90
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M126521-50mg 阿拉丁 50mg ¥1065.90
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M126521-250mg 阿拉丁 250mg ¥2297.90
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产品名称 MG-132
中文名称 MG-132,可逆蛋白酶体抑制剂
CAS号 133407-82-6
分子式（M.F.） C26H41N3O5
分子量（M.W.） 475.62
储存条件 -20°C储存
溶解性Soluble in DMSO (25 mg/ml), 100% ethanol (25 mg/ml), chloroform:methanol solution (95:5) (10 mg/ml), water (<1 mg/ml), and DMF (~25 mg/ml).
存贮条件储存温度-20°C
应用A proteasome and NF-κB inhibitor.
产品介绍MG-132是一种蛋白酶体抑制剂，IC50为100 nM，也抑制钙蛋白酶，IC50为1.2 μM。
备注MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM.
生化机理MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation, presenting broad relevance for aldehydic proteasome inhibitors of this type. MG-132 suppresses NF-κB activation (at 10 μM) by preventing IκB degradation (IC50=3 μM), which blocks the transcription factor from providing chemoresistance to cancer cells. It is also an an inhibitor of calpain. MG-132 [Z-Leu-Leu-Leu-CHO] is an inhibitor of 26S Proteasome and an activator of JNK1, c-Jun and c-Fos.
别名MG132;蛋白酶体抑制剂; N-[(苄氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-L-亮氨酰胺;Z-Leu-Leu-Leu-al;Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal;Calpain inhibitor IV-2; N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
搜索质检报告(COA)
搜索MSDS
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