| 溶解性 | Soluble in DMSO (3 mg/ml) at 60 °C, methanol (700 μg/ml), DMF (~0.15 mg/ml), and DMSO (10 mM). Insoluble in water |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | An antiproliferative agent, and inhibitor of DNA-PK. |
| 产品介绍 | NU7026是一种有效的DNA-PK抑制剂，IC50为0.23 μM，作用于DNA-PK比作用于PI3K选择性高60倍，抑制ATM和ATR活性。 |
| 备注 | NU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR. |
| 生化机理 | DNA-PK inhibitor II, a cell-permeable compound, is shown to be a potent inhibitor of DNA repair enzymes. DNA-PK inhibition makes it potentially possible to make cell lines become more sensitive to ionizing radiation (IR) and a reduction of lethal damage recovery could be possible. DNA-PK inhibitor II treatment of cells is shown to inhibit IR-induced DNA double strand break repair. |
| 别名 | NU 7026; 2-(4-吗啉基)-4H-萘并[1,2-b]吡喃-4-酮;LY293646; NU-7026; LY 293646; LY-293646;LY293646; NU-7026; LY 293646; LY-293646; 2-(Morpholin-4-yl)-benzo[h]chromen-4-one;DNA-PK Inhibitor II |
NU7026,可逆的DNA-PK抑制剂
NU7026 （订货以英文为准）
编号：N129741
CAS号：154447-35-5
分子式：C17H15NO3
分子量：281.31
| 产品名称 | NU7026 |
| 中文名称 | NU7026,可逆的DNA-PK抑制剂 |
| CAS号 | 154447-35-5 |
| MDL编码 | MFCD06798345 |
| 分子式（M.F.） | C17H15NO3 |
| 分子量（M.W.） | 281.31 |
| 储存条件 | 2-8°C储存 |
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