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NU7026,可逆的DNA-PK抑制剂

NU7026 （订货以英文为准）

编号：N129741
CAS号：154447-35-5
分子式：C17H15NO3
分子量：281.31
货号 品牌 包装 目录价 您的价格 库存 数量 购买
N129741-50mg 阿拉丁 50mg ¥1474.90
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N129741-10mg 阿拉丁 10mg ¥422.90
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产品名称 NU7026
中文名称 NU7026,可逆的DNA-PK抑制剂
CAS号 154447-35-5
MDL编码 MFCD06798345
分子式（M.F.） C17H15NO3
分子量（M.W.） 281.31
储存条件 2-8°C储存
溶解性Soluble in DMSO (3 mg/ml) at 60 °C, methanol (700 μg/ml), DMF (~0.15 mg/ml), and DMSO (10 mM). Insoluble in water
存贮条件储存温度 2-8°C
应用An antiproliferative agent, and inhibitor of DNA-PK.
产品介绍NU7026是一种有效的DNA-PK抑制剂，IC50为0.23 μM，作用于DNA-PK比作用于PI3K选择性高60倍，抑制ATM和ATR活性。
备注NU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.
生化机理DNA-PK inhibitor II, a cell-permeable compound, is shown to be a potent inhibitor of DNA repair enzymes. DNA-PK inhibition makes it potentially possible to make cell lines become more sensitive to ionizing radiation (IR) and a reduction of lethal damage recovery could be possible. DNA-PK inhibitor II treatment of cells is shown to inhibit IR-induced DNA double strand break repair.
别名NU 7026; 2-(4-吗啉基)-4H-萘并[1,2-b]吡喃-4-酮;LY293646; NU-7026; LY 293646; LY-293646;LY293646; NU-7026; LY 293646; LY-293646; 2-(Morpholin-4-yl)-benzo[h]chromen-4-one;DNA-PK Inhibitor II
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