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SMI-4a,ATP竞争性Pim激酶抑制剂

SMI-4a （订货以英文为准）

编号：T125988
CAS号：438190-29-5
分子式：C11H6F3NO2S
分子量：273.23
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T125988-10mg 阿拉丁 10mg ¥514.90
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T125988-50mg 阿拉丁 50mg ¥1501.90
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产品名称 SMI-4a
中文名称 SMI-4a,ATP竞争性Pim激酶抑制剂
CAS号 438190-29-5
MDL编码 MFCD01152003
分子式（M.F.） C11H6F3NO2S
分子量（M.W.） 273.23
储存条件 2-8°C储存
溶解性Soluble in DMSO (55 mg/ml at 25 °C), ethanol (32 mg/ml at 25 °C), and water (slightly at 25 °C).
存贮条件储存温度 2-8°C
应用A selective and ATP-competitive Pim kinase inhibitor
产品介绍SMI-4a是一种有效的Pim1抑制剂，IC50为17 nM，作用于Pim-2适度有效，抑制其他丝/苏氨酸或酪氨酸激酶作用不显著。
备注SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modest potent to Pim-2, does not significantly inhibit other serine/threonine- or tyrosine-kinases.
生化机理TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively). TCS PIM-1 4a has been shown to display selectivity over a panel of approximately 50 other kinases tested. This compound also exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro. TCS PIM-1 4a is an inhibitor of Aldose Reductase and Cox-2
别名(5Z)-5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮;SMI 4a;(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione; (Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione;TCS PIM-1 4a
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