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吡非尼酮

Pirfenidone （订货以英文为准）

编号：P129335
CAS号：53179-13-8
分子式：C12H11NO
分子量：185.22
货号 品牌 包装 目录价 您的价格 库存 数量 购买
P129335-100mg 阿拉丁 100mg ¥29.90
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P129335-250mg 阿拉丁 250mg ¥42.90
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P129335-1g 阿拉丁 1g ¥85.90
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P129335-5g 阿拉丁 5g ¥273.90
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P129335-25g 阿拉丁 25g ¥849.90
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P129335-100g 阿拉丁 100g ¥2699.90
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产品名称 Pirfenidone
中文名称 吡非尼酮
CAS号 53179-13-8
分子式（M.F.） C12H11NO
分子量（M.W.） 185.22
溶解性Soluble in water (>10 mg/ml at 60 °C), chloroform, DMSO (>20 mg/ml), ethanol, and DMF.
应用An antifibrotic and antioxidant small molecule
产品介绍Pirfenidone is a small molecule antifibrotic agent. In pulmonary fibrosis studies, Pirfenidone is shown to block collagen production and mitigate the presentation of bleomycin- and cyclophosphamide-induced fibrosis. This intervention appears in part on the transcriptional level, with Pirfenidone exposure correlating to a significant decrease in levels of procollagen I and III gene-assoicated messenger RNA. The antioxidant radical-scavenging activity additionally demonstrated by Pirfenidone suggests a role in protecting against lipid peroxidation, and may attribute to the antifibrotic property of the compound.
备注Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Phase 3.
生化机理Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.
别名5-甲基-1-苯基-2-(1H)-吡啶酮;吡非尼酮;5-Methyl-1-phenyl-2-pyridone; 5-Methyl-1-phenyl-2-(1H)-pyridone
标识符号https://www.aladdin-e.com/images/ghs/ghs02.jpg,https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Danger
危害声明H225,H302,H312,H319,H332
警示性声明P210,P280,P305+P351+P338
个人防护设备Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
风险声明 (欧洲)R11;R20/21/22;R36
安全声明（欧洲）S16;S36/37
危害码（欧洲）F,Xn
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