1. 首页
  2. 产品目录

AT-101,促凋亡剂

AT-101 （订货以英文为准）

编号：A127496
CAS号：90141-22-3
分子式：C30H30O8
分子量：518.55
货号 品牌 包装 目录价 您的价格 库存 数量 购买
A127496-50mg 阿拉丁 50mg ¥3317.00
请登录
A127496-10mg 阿拉丁 10mg ¥1053.00
请登录
产品名称 AT-101
中文名称 AT-101,促凋亡剂
CAS号 90141-22-3
分子式（M.F.） C30H30O8
分子量（M.W.） 518.55
溶解性DMSO >80 mg/ml Ethanol >80 mg/ml
存贮条件储存温度-20°C
生化机理AT-101 is orally bioavailable solvate of R-(-)-enantiomer of gossypol with potential antineoplastic activity. As a BH3 mimetic, AT-101 binds to the hydrophobic surface binding groove BH3 of the anti-apoptotic proteins Bcl-2 and Bcl-xL, blocking their heterodimerization with pro-apoptotic members of the Bcl-2 family of proteins such as Bad, Bid, and Bim; this may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. AT-101 induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. AT-101 delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.
搜索质检报告(COA)
搜索MSDS
相关产品