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Ro 31-8220 甲磺酸盐

Ro 31-8220 Mesylate （订货以英文为准）

编号：R129394
CAS号：138489-18-6
分子式：C26H27N5O5S2
分子量：553.65
货号 品牌 包装 目录价 您的价格 库存 数量 购买
R129394-10mg 阿拉丁 10mg ¥341.90
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R129394-50mg 阿拉丁 50mg ¥802.90
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R129394-5mg 阿拉丁 5mg ¥242.90
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R129394-100mg 阿拉丁 100mg ¥1132.90
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R129394-25mg 阿拉丁 25mg ¥394.90
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产品名称 Ro 31-8220 Mesylate
中文名称 Ro 31-8220 甲磺酸盐
CAS号 138489-18-6
分子式（M.F.） C26H27N5O5S2
分子量（M.W.） 553.65
储存条件 -20°C储存
溶解性DMSO 100 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
备注Ro 31-8220 is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.
生化机理Description:IC50 Value: 5, 24, 14, 27, and 24 nM (PKC α, PKC βI, PKC βII, PKC γ, and PKC) [1]Ro 31-8220, a staurosporine (sc-3510) analog, is a cell-permeable inhibitor of PKC (protein kinase C) isoforms PKC α, PKC βI, PKC βII, PKC γ, and PKC ε (IC50 = 5, 24, 14, 27, and 24 nM, respectively). Ro 31-8220 has also been shown to induce apoptosis in various cell lines, independent of its PKC activity, and to inhibit GSK 3 (IC50 = 6.8nM). Ro 31-8220 is an inhibitor of Cdk2, cyclin A, GSK-3β, MSK1, Pim-3, Polycystin-1, PRK2, Rsk-1 and Rsk-2 and an activator of JNK1.Ro 31-8220 antagonized (IC50, 1.0 microM) the effect of the activator of protein kinase C,12-O-tetradecanoylphorbol 13-acetate (TPA), on histamine-stimulated aminopyrine accumulation. Ro 31-8220 (0.1-2.14 microM) inhibited the aminopyrine response to 0.1 mM carbachol (IC50, 0.78 microM; 49% inhibition at 2.14 microM Ro 31-8220) and shifted
别名Bisindolylmaleimide IX Mesylate;Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1);Bisindolylmaleimide IX Mesylate;Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1)
标识符号https://www.aladdin-e.com/images/ghs/ghs02.jpg,https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Danger
危害声明H225,H302,H312,H319,H332
警示性声明P210,P280,P305+P351+P338
个人防护设备Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
WGK德国2
风险声明 (欧洲)R11;R20/21/22;R36
安全声明（欧洲）S16;S36/37
危害码（欧洲）F,Xn
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