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ZM 39923 盐酸盐

ZM 39923 HCl （订货以英文为准）

编号：Z129618
CAS号：1021868-92-7
分子式：C23H26CLNO
分子量：367.91
货号 品牌 包装 目录价 您的价格 库存 数量 购买
Z129618-250mg 阿拉丁 250mg ¥7209.90
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Z129618-10mg 阿拉丁 10mg ¥674.90
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Z129618-50mg 阿拉丁 50mg ¥2068.90
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产品名称 ZM 39923 HCl
中文名称 ZM 39923 盐酸盐
CAS号 1021868-92-7
MDL编码 MFCD04974534
分子式（M.F.） C23H26CLNO
分子量（M.W.） 367.91
储存条件 -20°C储存
溶解性DMSO 30 mg/mL Water <1 mg/mL Ethanol 8 mg/mL
存贮条件储存温度-20°C
产品介绍ZM39923盐酸盐是一种JAK1/3抑制剂, pIC50 of 4.4/7.1, 对JAK2几乎没有抑制活性。
生化机理ZM39923 is a JAK3 inhibitor. ZM39923 is also a potent inhibitor of TGM2 with IC50 of 10 nM. ZM39923 is reversible inhibitors when TGM2 is incubated with inhibitors in the absence of Ca2+. ZM39923 shows significant inhibition of crosslinking activity with IC50 of 25 nM in the absence of DTT and IC50 of 10 μM in the presence of DTT. ZM39923 prevents early death in a Drosophila Melanogaster model of a polyQ repeat disorder called Machado-Joseph Disease. ZM39923 inhibits the generation of AICD-FLAG and both Aβ40 and Aβ42 by purified γ-secretase in a concentration-dependent fashion with an approximate IC50 of 20 μM. ZM39923 decreases photoaffinity-labeled PS1-CTF in the presense of γ-secretase.
别名3-(异丙基(苄基)氨基)-1-(2-萘基)-1-丙酮盐酸盐;ZM-39923 hydrochloride; ZM39923 hydrochloride;3-((1-methylethyl)(phenylmethyl)amino)-1-(2-naphthalenyl)-1-propanone hydrochloride;
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