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20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸(20-HETE)

20-HETE （订货以英文为准）

编号：H126988
CAS号：79551-86-3
分子式：C20H32O3
分子量：320.47
货号 品牌 包装 目录价 您的价格 库存 数量 购买
H126988-50MG 阿拉丁 50MG ¥12555.00
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H126988-25MG 阿拉丁 25MG ¥7672.50
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H126988-10MG 阿拉丁 10MG ¥5301.00
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H126988-100MG 阿拉丁 100MG ¥19530.00
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H126988-5MG 阿拉丁 5MG ¥3487.50
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H126988-10ug 阿拉丁 10ug ¥6599.00
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H126988-10μg 阿拉丁 10μg ¥6797.90
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H126988-25μg 25μg ¥3339.90
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H126988-50μg 50μg ¥6426.90
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产品名称 20-HETE
中文名称 20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸(20-HETE)
CAS号 79551-86-3
MDL编码 MFCD00171542
分子式（M.F.） C20H32O3
分子量（M.W.） 320.47
储存条件 避光;-20°C储存
溶解性25°C: DMSO
存贮条件储存温度-20°C
产品介绍20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid
生化机理Description:IC50 Value: N/A20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450-derived arachidonic acid metabolite that has been shown to increase smooth muscle contractions and proliferation, stimulate endothelial dysfunction and activation and promote hypertension.in vitro: Addition of 20-HETE to the bath (1-100 nM), reduced the frequency of opening of the large-conductance Ca(2+)-activated K+ channel recorded using cell-attached patches on VSM [1]. In kidney, 20-HETE induces diuresis by inhibiting Na+-K+-ATPase in proximal tubules  and Na+/K+/Cl+ cotransporter in the thick ascending limb of Henle's loop [2].in vivo: In Cyp4a14(-/-) mice, which display androgen-driven and 20-HETE-dependent hypertension, treatment with20-HETE antagonist abolished remodeling of renal resistance arteries measured as media thickness (24±1 vs. 15±1μm) and M/L (0.29±0.03 vs. 0.17±0.01) [4].  The transgenic mice
别名;20-Hydroxyarachidonic acid，20-HETE
标识符号https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Warning
危害声明H319-H413
警示性声明P305 + P351 + P338
WGK德国3
搜索质检报告(COA)
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