| 溶解性 | DMSO 100 mg/mL Water <1 mg/mL Ethanol 100 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | AT406 (SM-406, ARRY-334543) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to |
| 生化机理 | AT-406 (formerly known as SM-406) is an orally bioavailable potent IAP (inhibitor of apoptosis protein) of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively. This may restore and promote the induction of apoptosis through apoptotic signaling pathways. AT-406 may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains. AT-406 is currently in Phase I clinical trial in patients with advanced solid tumors and lymphomas. |
| 别名 | (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxo-decahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide;(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxo-decahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide |
AT406 (SM-406)
AT406 (SM-406) （订货以英文为准）
编号：A126412
CAS号：1071992-99-8
分子式：C32H43N5O4
分子量：561.71
| 产品名称 | AT406 (SM-406) |
| 中文名称 | AT406 (SM-406) |
| CAS号 | 1071992-99-8 |
| 分子式（M.F.） | C32H43N5O4 |
| 分子量（M.W.） | 561.71 |
| 储存条件 | -20°C储存 |
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