| 溶解性 | Soluble in ethanol (5 mg/ml warm), DMSO (4 mg/ml), DMF (10 mg/ml), methylene chloride, chloroform, methanol (7 mg/ml), and benzene |
| 存贮条件 | 储存温度2-8℃ |
| 应用 | A hedgehog [Hh] signaling pathway and Smo inhibitor. |
| 产品介绍 | Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂，作用于Smoothened (Smo)，IC50为46 nM。 |
| 备注 | Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM. |
| 生化机理 | Cyclopamine is a teratogenic Smo inhibitor famous for inducing cyclopia in developing mammalian fetuses. Cyclopia arises from improper differentiation in the fetus, a process heavily regulated by the Hedgehog (Hh) signaling pathway. The proteins Smo and patched mediate cellular response to the Hedgehog protein signal, and aberrant behavior of these proteins can lead to oncogenic states. While cyclopia and fetal failure are the notorious effects of cyclopamine on development, the compound has also been used to suppress and reverse the effects of oncogenic mutations in Smo and patched. |
| 别名 | 环巴胺; 去氧芥芬胺;11-Deoxojervine;(3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol |
环巴胺
Cyclopamine （订货以英文为准）
编号：C125994
CAS号：4449-51-8
分子式：C27H41NO2
分子量：411.62
| 产品名称 | Cyclopamine |
| 中文名称 | 环巴胺 |
| CAS号 | 4449-51-8 |
| 分子式（M.F.） | C27H41NO2 |
| 分子量（M.W.） | 411.62 |
| 储存条件 | 2-8°C储存 |
| Reaxys-RN | 5307824 |
| Merck Index | 3592 |
| 个人防护设备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
| RTECS | VB1993650 |
| WGK德国 | 3 |
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