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Bavisant,人H3受体拮抗剂

Bavisant （订货以英文为准）

编号：B126313
CAS号：929622-08-2
分子式：C19H27N3O2
分子量：329.44
货号 品牌 包装 目录价 您的价格 库存 数量 购买
B126313-5mg 阿拉丁 5mg ¥1514.90
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B126313-10mg 阿拉丁 10mg ¥3014.90
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B126313-100mg 阿拉丁 100mg ¥12472.90
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B126313-25mg 阿拉丁 25mg ¥6322.90
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B126313-50mg 阿拉丁 50mg ¥8017.90
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产品名称 Bavisant
中文名称 Bavisant,人H3受体拮抗剂
CAS号 929622-08-2
分子式（M.F.） C19H27N3O2
分子量（M.W.） 329.44
储存条件 -20°C储存
溶解性25°C: DMSO
存贮条件储存温度-20°C
生化机理Description:IC50 Value: N/ABavisant (JNJ-31001074) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. Bavisant completed a phase II ADHD trial, but no results have been reported [1].in vitro: N/Ain vivo: Mean change from baseline in the total ADHD-RS-IV score at day 42 (primary efficacy endpoint) was -8.8 in the placebo group versus -9.3, -11.2 and -12.2 in the bavisant 1?mg/day, 3?mg/day and 10?mg/day groups, respectively; the change in the 10?mg/day group was not statistically superior to placebo (p=0.161), and hence statistical comparisons of the 1?mg/day and 3?mg/day groups with placebo based on a step-down closed testing procedure were not performed [2].Clinical trial: A Study to Characterize the Pharmacokinetics and Effect of Food on JNJ-31001074 in Healthy Volunteers. Phase 2
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