熔点 | 109-111° C |
折光率 | 1.62 |
溶解性 | DMSO 21 mg/mL Water <1 mg/mL Ethanol 20 mg/mL |
存贮条件 | 储存温度-20°C |
应用 | Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death. |
产品介绍 | SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
备注 | SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
生化机理 | SANT-1 inhibited Sonic hedgehog signaling and induced apoptosis via Ras/NF-κB pathway in glioblastoma cells. SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency. |
别名 | (E)-N-(4-苄基-1-哌嗪基)-1-(3,5-二甲基-1-苯基-1H-吡唑-4-基)甲亚胺;(E)-N-(4-Benzyl-1-piperazinyl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine;(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine |
SANT-1,平滑刺猬信号拮抗剂
SANT-1 (订货以英文为准)
编号:S129830
CAS号:304909-07-7
分子式:C23H27N5
分子量:373.49
产品名称 | SANT-1 |
中文名称 | SANT-1,平滑刺猬信号拮抗剂 |
CAS号 | 304909-07-7 |
分子式(M.F.) | C23H27N5 |
分子量(M.W.) | 373.49 |
储存条件 | -20°C储存 |
标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
信号词 | Warning |
危害声明 | H302-H351 |
警示性声明 | P281 |
RTECS | UX9590000 |
WGK德国 | 3 |
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