SANT-1,平滑刺猬信号拮抗剂

SANT-1 (订货以英文为准)

编号:S129830
CAS号:304909-07-7
分子式:C23H27N5
分子量:373.49
货号 品牌 包装 目录价 您的价格 库存 数量 购买
S129830-5mg 阿拉丁 5mg ¥288.90
S129830-100mg 阿拉丁 100mg ¥866.90
S129830-25mg 阿拉丁 25mg ¥583.90
产品名称 SANT-1
中文名称 SANT-1,平滑刺猬信号拮抗剂
CAS号 304909-07-7
分子式(M.F.) C23H27N5
分子量(M.W.) 373.49
储存条件 -20°C储存
熔点109-111° C
折光率1.62
溶解性DMSO 21 mg/mL Water <1 mg/mL Ethanol 20 mg/mL
存贮条件储存温度-20°C
应用Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death.
产品介绍SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.
备注SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.
生化机理SANT-1 inhibited Sonic hedgehog signaling and induced apoptosis via Ras/NF-κB pathway in glioblastoma cells. SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.
别名(E)-N-(4-苄基-1-哌嗪基)-1-(3,5-二甲基-1-苯基-1H-吡唑-4-基)甲亚胺;(E)-N-(4-Benzyl-1-piperazinyl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine;(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
标识符号https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg
信号词Warning
危害声明H302-H351
警示性声明P281
RTECSUX9590000
WGK德国3
搜索质检报告(COA)
搜索MSDS
相关产品