| 溶解性 | DMSO 73 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | S3I-201 |
| 备注 | S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM, and low activity towards STAT1 and STAT5. |
| 生化机理 | NSC 74859 (S3I-201) inhibits Stat3-Stat3 complex formation and Stat3 DNA-binding (IC50 =86 ±33μM) and transcriptional activities. Furthermore, S31-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3. NSC 74859 (S3I-201) inhibits the expression of the Stat3-regulated genes encoding cyclin D1, BcI-xL, and survivin and inhibits the growth of human breast tumors in vivo. Therefore the antitumor activity of S31-201 is mediated in part through inhibition of aberrant Stat3 activation and provide the proof-of-concept for the potential clinical use of Stat3 inhibitors such as NSC 74859 (S31-201) in tumors harboring aberrant Stat3. |
| 别名 | 2-hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid;2-hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid |
S3I-201,STAT3抑制剂
S3I-201 （订货以英文为准）
编号：S129625
CAS号：501919-59-1
分子式：C16H15NO7S
分子量：365.36
| 产品名称 | S3I-201 |
| 中文名称 | S3I-201,STAT3抑制剂 |
| CAS号 | 501919-59-1 |
| 分子式（M.F.） | C16H15NO7S |
| 分子量（M.W.） | 365.36 |
| 储存条件 | -20°C储存;充氩 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs05.jpg |
| 信号词 | Danger |
| 危害声明 | H318 |
| 警示性声明 | P280-P305 + P351 + P338 |
| 个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
| RTECS | US7975550 |
| WGK德国 | 3 |
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