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SGI-1776 游离碱

SGI-1776 free base （订货以英文为准）

编号：S126376
CAS号：1025065-69-3
分子式：C20H22F3N5O
分子量：405.42
货号 品牌 包装 目录价 您的价格 库存 数量 购买
S126376-10mg 阿拉丁 10mg ¥1158.90
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S126376-5mg 阿拉丁 5mg ¥764.90
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S126376-50mg 阿拉丁 50mg ¥4075.90
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产品名称 SGI-1776 free base
中文名称 SGI-1776 游离碱
CAS号 1025065-69-3
分子式（M.F.） C20H22F3N5O
分子量（M.W.） 405.42
储存条件 -20°C储存
溶解性DMSO ≥80mg/mL Water <1.2mg/mL Ethanol ≥80mg/mL
存贮条件储存温度-20°C
应用A potent apoptotic that targets Pim and FLT3 in AML and CLL cells.
产品介绍SGI-1776 free base是一种新型的，ATP竞争性的Pim1抑制剂，IC50为7 nM，比作用于Pim2和Pim3选择性分别高50和10倍，作用于Flt3和haspin也有效。
备注SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
生化机理SGI-1776 is a novel ATP-competitive inhibitor of Pim-1, Pim-2, and Pim-3 (IC50 = 7, 363, and 69 nM, respectively). In addition to inhibiting Pim, this compound also inhibits FLT3 (IC50 = 44 nM). SGI-1776 is also cytotoxic in AML primary cells, regardless of the FLT3 mutation status, which results in Mcl-1 protein decline. SGI-1776 inhibits tumor growth for intermediate EFS T/C activity in 1 of 39 evaluable models.
别名SGI1776; N-[(1-甲基-4-哌啶基)甲基]-3-[3-(三氟甲氧基)苯基]-咪唑并[1,2-b]哒嗪-6-胺;SGI 1776; SGI1776;SGI-1776;N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine
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