| 溶解性 | DMSO 54 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | An HDAC1, HDAC3, HDAC6, and HDAC8 inhibitor |
| 产品介绍 | CI-994 (Tacedinaline)是抗癌化合物，能抑制HDAC1，IC50为0.57 μM，能促使细胞周期停滞于G1期。 |
| 备注 | CI-994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM and causes G1 cell cycle arrest. Phase 3. |
| 生化机理 | Description: IC50 Value: 0.57 uM (For HDAC1,MTT assay) CI-994 (N-acetyldinaline) is a novel oral compound with a wide spectrum of antitumor activity in preclinical models, in vitro and in vivo. The mechanism of action may involve inhibition of histone deacetylation and cell cycle arrest[1]. in vitro: Different CI-994 concentrations were tested, ranging from 0.01 to 160 microM at 24, 48, and 72 h of treatment inA-549 (adenocarcinoma) and LX-1 (squamous cell carcinoma) ,with MTT assay. A concentration-dependent cell survival inhibition was observed, with an IC50 at 80 microM. The effect of CI-994, as demonstrated by recovery experiments, was cytostatic and seemed to be superimposable in both cell lines. Cytofluorimetric analysis to assess cell cycle perturbation and apoptosis was performed after 24 h of treatment, indicating a cell block with concomitant increase at G0/G1 phase, a reduction at S phase level at 20, 40, 80, and 160 microM, and apoptosis at the higher conce |
| 别名 | PD-123654;4-乙酰氨基-N-(2-氨基苯基)苯甲酰胺;乙酰地那林;Acetyldinaline;Tacedinaline;PD 123654;Goe 5549;CI 994;CI994; 4-Acetylamino-N-(2′-aminophenyl)benzamide ; |
乙酰地那林
CI-994 （订货以英文为准）
编号：C126432
CAS号：112522-64-2
分子式：C15H15N3O2
分子量：269.30
| 产品名称 | CI-994 |
| 中文名称 | 乙酰地那林 |
| CAS号 | 112522-64-2 |
| MDL编码 | MFCD00866266 |
| 分子式（M.F.） | C15H15N3O2 |
| 分子量（M.W.） | 269.30 |
| 储存条件 | -20°C储存 |
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