| 沸点 | 630.08° C at 760 mmHg |
| 熔点 | 268.39° C |
| 折光率 | 1.78 |
| 溶解性 | DMSO ≥70mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.5600 |
| 应用 | An AMPK activator which induces PI3-kinase-dependent glucose uptake |
| 产品介绍 | A-769662是可逆的AMPK活化剂，EC50为800nM，对GPPase/FBPase几乎无活性。 |
| 备注 | A-769662 is a potent, reversible AMPK activator with EC50of 0.8 μM, little effect on GPPase/FBPase activity. |
| 生化机理 | A-769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 μM) that displays selectivity towards β1 subunit-containing heterotrimers. A-769662 inhibits fatty acid synthesis (IC50 = 3.2 μM) and decreases plasma glucose and triglyceride levels in vivo. |
| 别名 | 4-羟基-3-(2'-羟基-1,1'-联苯-4-基)-6-氧代-6,7-二氢噻吩并(2,3-b)吡啶-5-甲腈;A769662;6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile; 4-hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno(2,3-b)pyridine-5-carbonitrile |
A-769662,AMP激活的蛋白激酶激活剂
A-769662 （订货以英文为准）
编号：A127825
CAS号：844499-71-4
分子式：C20H12N2O3S
分子量：360.39
| 产品名称 | A-769662 |
| 中文名称 | A-769662,AMP激活的蛋白激酶激活剂 |
| CAS号 | 844499-71-4 |
| 分子式（M.F.） | C20H12N2O3S |
| 分子量（M.W.） | 360.39 |
| 储存条件 | -20°C储存 |
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