沸点 | 628.01° C at 760 mmHg |
熔点 | 229.98° C |
折光率 | 1.71 |
溶解性 | DMSO 33 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
存贮条件 | 储存温度-20°C |
密度 | 1.4200 |
应用 | A cell-permeable, potent, selective and ATP-competitive ATM inhibitor |
产品介绍 | KU-55933是ATM抑制剂,IC50和Ki分别为13和2.2 nM,对DNA-PK,PI3K/PI4K,ATR和mTOR的活性较低。 |
生化机理 | KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1. |
别名 | KU 55933; KU55933;2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮;KU 55933;KU55933;2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one |
KU-55933(ATM激酶抑制剂)
KU-55933 (ATM Kinase Inhibitor) (订货以英文为准)
编号:K126884
CAS号:587871-26-9
分子式:C21H17NO3S2
分子量:395.49
产品名称 | KU-55933 (ATM Kinase Inhibitor) |
中文名称 | KU-55933(ATM激酶抑制剂) |
CAS号 | 587871-26-9 |
分子式(M.F.) | C21H17NO3S2 |
分子量(M.W.) | 395.49 |
储存条件 | -20°C储存 |
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