KU-55933(ATM激酶抑制剂)

KU-55933 (ATM Kinase Inhibitor) (订货以英文为准)

编号:K126884
CAS号:587871-26-9
分子式:C21H17NO3S2
分子量:395.49
货号 品牌 包装 目录价 您的价格 库存 数量 购买
K126884-100mg 阿拉丁 100mg ¥1615.90
K126884-5mg 阿拉丁 5mg ¥280.90
K126884-25mg 阿拉丁 25mg ¥674.90
产品名称 KU-55933 (ATM Kinase Inhibitor)
中文名称 KU-55933(ATM激酶抑制剂)
CAS号 587871-26-9
分子式(M.F.) C21H17NO3S2
分子量(M.W.) 395.49
储存条件 -20°C储存
沸点628.01° C at 760 mmHg
熔点229.98° C
折光率1.71
溶解性DMSO 33 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
密度1.4200
应用A cell-permeable, potent, selective and ATP-competitive ATM inhibitor
产品介绍KU-55933是ATM抑制剂,IC50和Ki分别为13和2.2 nM,对DNA-PK,PI3K/PI4K,ATR和mTOR的活性较低。
生化机理KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.
别名KU 55933; KU55933;2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮;KU 55933;KU55933;2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one
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