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MK-4827( 尼拉帕尼)

MK-4827 (Niraparib) （订货以英文为准）

编号：M127627
CAS号：1038915-60-4
分子式：C19H20N4O
分子量：320.39
货号 品牌 包装 目录价 您的价格 库存 数量 购买
M127627-100mg 阿拉丁 100mg ¥299.90
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M127627-10mg 阿拉丁 10mg ¥59.90
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M127627-50mg 阿拉丁 50mg ¥169.90
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M127627-5g 阿拉丁 5g ¥4927.90
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M127627-250mg 阿拉丁 250mg ¥569.90
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M127627-1g 阿拉丁 1g ¥1407.90
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产品名称 MK-4827 (Niraparib)
中文名称 MK-4827( 尼拉帕尼)
CAS号 1038915-60-4
分子式（M.F.） C19H20N4O
分子量（M.W.） 320.39
储存条件 -20°C储存
溶解性DMSO
存贮条件储存温度-20°C
产品介绍MK-4827(Niraparib)是高活性PARP1/PARP2抑制剂，IC50分别为3.8 nM/2.1 nM，在BRCA-1和BRCA-2突变型肿瘤细胞中具有很好的活性，比对PARP3，V-PARP和Tank1的抑制性高330倍以上。
备注MK-4827 is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Phase 3.
生化机理MK-4827 is a potent, selective, PARP 1/2 inhibitor with IC50 of 3.8 and 2.1 nM for PARP1 and 2, respectively. MK-4827 possesses potential antineoplastic activity. In a whole cell assay, MK-4827 prevented PARP activity with an EC50 of 4 nM, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. MK-4827 induces selective synthetic lethality in homologous recombination (HR) repair deficient tumors with BRCA1/2 loss and tumor cell lines with non-BRCA-related HR defects, supporting clinical utility in sporadic tumors. MK-4827 reveals good pharmacokinetic properties and is currently in phase I clin. trials. The phase I clinical trials for MK-4827 is ongoing in the treatment of solid tumors.
别名2-[4-((3S)-3-哌啶基)苯基]-2H-吲唑-7-甲酰胺;Niraparib;MK 4827;MK4827;2-[4-((3S)-3-Piperidinyl)phenyl]-2H-indazole-7-carboxamide
标识符号https://www.aladdin-e.com/images/ghs/ghs08.jpg
信号词Danger
危害声明H360
警示性声明P201-P308 + P313
个人防护设备Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSTU5570250
WGK德国3
搜索质检报告(COA)
搜索MSDS
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