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洛莫司汀

Lomustine （订货以英文为准）

编号：L123247
CAS号：13010-47-4
分子式：C9H16N3O2CL
分子量：233.70
货号 品牌 包装 目录价 您的价格 库存 数量 购买
L123247-250mg 阿拉丁 250mg ¥411.90
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L123247-1g 阿拉丁 1g ¥1519.90
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L123247-50mg 阿拉丁 50mg ¥187.90
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L123247-200mg 阿拉丁 200mg ¥367.90
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产品名称 Lomustine
中文名称 洛莫司汀
CAS号 13010-47-4
分子式（M.F.） C9H16N3O2CL
分子量（M.W.） 233.70
储存条件 -20°C储存
熔点89.0-93.0°C
存贮条件储存温度-20°C
应用带有影响细胞DNA的抗肿瘤药物。洛莫司汀诱导A2870细胞p53的表达
生化机理Description:IC50 Value: N/ALomustine (or "CCNU")(Marketed under the name CeeNU in US) is an alkylating nitrosourea compound used in chemotherapy.in vitro: vincristine and lomustine trigger apoptosis in all these cells through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively [1]. There was significant correlation between the level of cadherin-associated protein beta 1 (CTNNB1) and Aurora kinase A (STK15) proteins and neurotrophic tyrosine kinase receptor type 3 (TRKC) mRNA and the proportion of apoptosis induced by vincristine, the combination of both drugs, and lomustine, respectively [4].in vivo: IC50 values for CCNU admixed and encapsulated with lipid vesicles were 18+/-4.9 and 14.0+/-2.2 microM, respectively, compared to 83+/-11.0 microM for free CCNU in rats [2]. Eight of the 19 dogs (42%) had a measurable response to CCNU. One dog had a durable complete response for
别名1-(2-氯乙基)-3-环己基-1-亚硝基脲;1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
Reaxys-RN3572117
Merck Index86
标识符号https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Warning
危害声明H315,H319,H335
警示性声明P261,P305+P351+P338
个人防护设备dust mask type N95 (US),Eyeshields,Gloves
RTECSFZ9680000
WGK德国3
风险声明 (欧洲)R36/37/38
安全声明（欧洲）S26;S36
危害码（欧洲）Xi
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