| 沸点 | ~624.4° C at 760 mmHg |
| 熔点 | 243.14° C |
| 折光率 | 1.66 |
| 溶解性 | DMSO 72 mg/mL Water 72 mg/mL Ethanol 18 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.2000 |
| 应用 | A selective Akt1, PKA, and CDK2 inhibitor |
| 产品介绍 | A-674563是Akt1抑制剂，IC50为14 nM，还能抑制PKA和CDK2，IC50分别为16和46 nM。 |
| 备注 | A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. |
| 生化机理 | A-674563 is achieved from A-443654 by replacing the indole with a phenyl moiety and getting oral activity. A-674563 slows proliferation of tumor cells with EC50 of 0.4 μM. A-674563 does not inhibit Akt phosphorylation per se, but blocks the phosphorylation of Akt downstream targets in a dose-dependent manner. A-674563 induced Akt blockade results in decreased STS cell downstream target phosphorylation and tumor cell growth inhibiton. A-674563 induces G2 cell cycle arrest and apoptosis in STS cells. |
| 别名 | A 674563; A674563;(alphas)-alpha-(((5-(3-methyl-1h-indazol-5-yl)-3-pyridinyl)oxy)methyl)benzeneethanamine;(2s)-1-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-Phenylpropan-2-Amine;A 674563; A674563; (alphaS)-alpha-(((5-(3-甲基-1H-吲唑-5-基)-3-吡啶基)氧)甲基)苯乙胺; |
A-674563
A-674563 （订货以英文为准）
编号：A126845
CAS号：552325-73-2
分子式：C22H22N4O
分子量：358.44
| 产品名称 | A-674563 |
| 中文名称 | A-674563 |
| CAS号 | 552325-73-2 |
| 分子式（M.F.） | C22H22N4O |
| 分子量（M.W.） | 358.44 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs06.jpg |
| 信号词 | Danger |
| 危害声明 | H301 |
| 警示性声明 | P301+P310 |
| 个人防护设备 | Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges |
| RTECS | CF3325000 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | R25 |
| 安全声明（欧洲） | S7,S35,S45 |
| 危害码（欧洲） | T |
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