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Ganetespib(STA-9090),Hsp90抑制剂

Ganetespib (STA-9090) （订货以英文为准）

编号：G127078
CAS号：888216-25-9
分子式：C20H20N4O3
分子量：364.40
货号 品牌 包装 目录价 您的价格 库存 数量 购买
G127078-50MG 阿拉丁 50MG ¥999.90
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G127078-5mg 阿拉丁 5mg ¥239.90
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G127078-10MG 阿拉丁 10MG ¥339.90
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G127078-25mg 阿拉丁 25mg ¥599.90
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G127078-100mg 阿拉丁 100mg ¥1599.90
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G127078-50mg(存档) 阿拉丁 50mg(存档) ¥236.90
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G127078-10mg(存档) 阿拉丁 10mg(存档) ¥236.90
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G127078-1mg 阿拉丁 1mg ¥75.90
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产品名称 Ganetespib (STA-9090)
中文名称 Ganetespib(STA-9090),Hsp90抑制剂
CAS号 888216-25-9
分子式（M.F.） C20H20N4O3
分子量（M.W.） 364.40
储存条件 -20°C储存
溶解性DMSO 40 mg/mL Water <1 mg/mL Ethanol 9 mg/mL
存贮条件储存温度-20°C
应用A unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM for OSA 8 cells
产品介绍Ganetespib(STA-9090)是含三唑酮的Hsp90抑制剂，在OSA 8细胞中IC50为4 nM。
备注Ganetespib is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474.
生化机理Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM for OSA 8 cells. Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor Ganetespib binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional HsP90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic
别名STA-9090;STA 9090;STA9090；3-(2,4-二羟基-5-异丙基苯基)-4-(1-甲基吲哚-5-基)-5-羟基-4H-1,2,4-三唑; ganetespib;;STA-9090;STA 9090;STA9090；3-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methylindol-5-yl)-5-hydroxy-4h-1,2,4-triazole; 5-(2,4-dihydroxy-5-(1-methylethyl)phenyl)-2,4-dihydro-4-(1-methyl-1h-indol-5-yl)-3h-1,2,4-triazol-3-one
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