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LY364947,TGFβR-I抑制剂

LY364947 （订货以英文为准）

编号：L129343
CAS号：396129-53-6
分子式：C17H12N4
分子量：272.30
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L129343-5mg 阿拉丁 5mg ¥380.90
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L129343-50mg 阿拉丁 50mg ¥2396.90
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L129343-10mg 阿拉丁 10mg ¥610.90
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产品名称 LY364947
中文名称 LY364947,TGFβR-I抑制剂
CAS号 396129-53-6
MDL编码 MFCD00800758
分子式（M.F.） C17H12N4
分子量（M.W.） 272.30
储存条件 2-8°C储存
熔点230 °C
溶解性Soluble in DMSO (100 mM), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMF (~0.1 mg/ml), and 1:1 DMF:PBS (pH 7.2) (~0.5 mg/ml).
存贮条件储存温度 2-8°C
应用A selective ATP-competitive inhibitor of TGF-β Receptor I kinase.
产品介绍LY364947是一种有效的，ATP竞争性的TGFβR-I抑制剂，IC50为59 nM，比作用于TGFβR-II选择性高7倍。
备注LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, shows 7-fold selectivity over TGFβR-II.
生化机理LY 364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase). Studies of mouse fibroblasts show that LY 364947 inhibits cellular growth and transcription activation via TGF-β Receptor I kinase inhibition. In addition, TGF-β Receptor I kinase is responsible for fibroblast proliferation and the accumulation of astrocytes around the fibrotic scar when injury occurs to cells. In vitro studies report that in the presence of LY 364947 the amount of reactive astrocytes at the lesion site is also reduced. Furthermore, studies show that LY 364947 strongly effects intraplug vasculature by increasing the extravasation of Dextran . LY 364947 is an inhibitor of eIF2 alpha, MLTK, p38 alpha and TGF β RII.
别名4-[3-(2-吡啶基)-1H-吡唑-4-基]喹啉;HTS466284; LY-364947;TGF-β RI Kinase Inhibitor; 3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole; 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline ;HTS 466284 ;Transforming Growth Factor-β Type I Receptor Kinase Inhibitor
标识符号https://www.aladdin-e.com/images/ghs/ghs06.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg
信号词Danger
危害声明H300+310+H330,H350
警示性声明P201,P260,P264,P280,P284,P301+P310
个人防护设备Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSGY1925000
WGK德国3
风险声明 (欧洲)R45;R46;R26/27/28
安全声明（欧洲）S53;S28;S36/37;S45
危害码（欧洲）T+
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