| 溶解性 | Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml). |
| 存贮条件 | 储存温度-20°C |
| 应用 | An HDAC inhibitor reported to inhibit human multiple myeloma cell lines. |
| 产品介绍 | Panobinostat (LBH589)是一种新型的，广谱的HDAC抑制剂，IC50为5 nM。Phase 3。 |
| 备注 | Panobinostat (LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM. Phase 3. |
| 生化机理 | Panobinostat (LBH589) is a HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. The deacetylation of histones is associated with transcriptional silencing. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells. |
| 别名 | 帕比司他;LBH-589; LBH589; NVP-LBH589;(E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide;N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide |
帕比司他
Panobinostat (LBH589) （订货以英文为准）
编号：P125167
CAS号：404950-80-7
分子式：C21H23N3O2
分子量：349.43
| 产品名称 | Panobinostat (LBH589) |
| 中文名称 | 帕比司他 |
| CAS号 | 404950-80-7 |
| MDL编码 | MFCD09833242 |
| 分子式（M.F.） | C21H23N3O2 |
| 分子量（M.W.） | 349.43 |
| 储存条件 | -20°C储存 |
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