| 沸点 | 796.7° C at 760 mmHg |
| 折光率 | 1.68 |
| 溶解性 | DMSO ≥100mg/mL Water ≥100mg/mL Ethanol ≥2.8mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A highly selective ARK-2 inhibitor |
| 产品介绍 | AZD1152-HQPA是AZD-1152的活性代谢物，AZD1152-HQPA (Barasertib)是Aurora B 高选择性抑制剂，IC50为0.37 nM，比对Aurora A的抑制性高100倍。 |
| 备注 | AZD1152-HQPA (Barasertib) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM, ~100 fold more selective for Aurora B over Aurora A. |
| 生化机理 | AZD1152-HQPA is the active metabolite of AZD-1152, a potent selective Aurora Kinase B inhibitor. AZD1152 is 50-fold selective for Aurora kinase B over Aurora kinase C and over 1000-fold selective for Aurora kinase B over Aurora Kinase A. (IC50s: aurora-A, 1,369 nmol/L; aurora-B, 0.36 nmol/L; aurora-C, 17.0 nmol/L). It is converted in plasma to the active form AZD1152-HQPA, which has been shown to have antineoplastic activity in a variety of animal models and human cancer cell lines. |
| 别名 | AZD1152; AZD 1152; 5-((7-(3-(乙基(2-羟基乙基)氨基)丙氧基)-4-喹唑啉)氨基)-N-(3-氟苯基)-1H-吡唑-3-乙酰胺;;Barasertib;5-((7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)-4-quinazolinyl)amino)-n-(3-fluorophenyl)-1h-pyrazole-3-acetamide；3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide |
Barasertib (AZD1152-HQPA),Aurora B激酶抑制剂
Barasertib (AZD1152-HQPA) （订货以英文为准）
编号：A127799
CAS号：722544-51-6
分子式：C26H30FN7O3
分子量：507.56
| 产品名称 | Barasertib (AZD1152-HQPA) |
| 中文名称 | Barasertib (AZD1152-HQPA),Aurora B激酶抑制剂 |
| CAS号 | 722544-51-6 |
| MDL编码 | MFCD10687152 |
| 分子式（M.F.） | C26H30FN7O3 |
| 分子量（M.W.） | 507.56 |
| 储存条件 | -20°C储存 |
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