| 溶解性 | DMSO 13 mg/mL (32.79 mM); Water <1 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM) |
| 存贮条件 | 储存温度-20°C |
| 应用 | A potent inhibitor of HDAC1, HDAC2, HDAC3, and HDAC11. |
| 产品介绍 | Mocetinostat (MGCD0103)是一种有效的HDAC抑制剂，对HDAC1抑制作用最强，IC50为0.15 μM，比作用于HDAC2， 3，和11选择性高2到10倍，对HDAC4， 5， 6， 7，和8没有抑制活性。Phase 2。 |
| 备注 | Mocetinostat (MGCD0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Phase 1/2. |
| 生化机理 | MGCD0103 potently inhibits a subset of the nine human recombinant HDACs, including HDAC1, HDAC2, HDAC3, and HDAC11. MGCD0103 reveals most potent inhibitory activity against human HDAC1 and HDAC2 enzymes in vitro, and it does not inhibit class II HDACs. The inhibitory activity of MGCD0103 reaches the maximum plateau at 6 μM, and the maximal inhibitable enzyme pool affected by MGCD0103 is 75% of the total enzyme activity in HCT116 cells. |
| 别名 | N-(2-氨基苯基)-4-([[4-(吡啶-3-基)嘧啶-2-基]氨基]甲基)苯甲酰胺;MGCD0103;MGCD 0103;MGCD-0103;N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide |
Mocetinostat(MGCD0103),HDAC抑制剂
Mocetinostat (MGCD0103) （订货以英文为准）
编号：M126151
CAS号：726169-73-9
分子式：C23H20N6O
分子量：396.44
| 产品名称 | Mocetinostat (MGCD0103) |
| 中文名称 | Mocetinostat(MGCD0103),HDAC抑制剂 |
| CAS号 | 726169-73-9 |
| 分子式（M.F.） | C23H20N6O |
| 分子量（M.W.） | 396.44 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H302-H312-H315-H317-H319-H332-H335 |
| 警示性声明 | P261-P280-P305 + P351 + P338 |
| 个人防护设备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| RTECS | MI5215000 |
| WGK德国 | 3 |
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