| 溶解性 | DMSO >70 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度2-8°C |
| 产品介绍 | FG-4592是一种HIF α脯氨酰羟化酶抑制剂，并能稳定HIF-2，同时诱导EPO产生。 |
| 备注 | FG-4592 is an HIF αprolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production. Phase 2/3. |
| 生化机理 | FG-4592 is an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. A phase II clinical trial of FG-4592 has been competed in the treatment of chronic kidney disease. |
| 别名 | N-[(4-羟基-1-甲基-7-苯氧基-3-异喹啉基)羰基]甘氨酸;FG4592;FG 4592;N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine;[[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid |
FG-4592,HIF-α脯氨酰羟化酶抑制剂
FG-4592 （订货以英文为准）
编号：F126178
CAS号：808118-40-3
| 产品名称 | FG-4592 |
| 中文名称 | FG-4592,HIF-α脯氨酰羟化酶抑制剂 |
| CAS号 | 808118-40-3 |
| 储存条件 | -20°C储存 |
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