| 熔点 | 178.44° C |
| 折光率 | 1.54 |
| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.6000 |
| 应用 | A selective large conductance calcium activated potassium channel activator |
| 产品介绍 | BIX01294是G9a组蛋白甲基转移酶（HMTase）抑制剂，IC50为2.7 μM。 |
| 生化机理 | BIX-01294, a diazepin-quinazolinamine derivative, is a selective inhibitor of G9a histone methyl transferase (G9a HMTase) that impairs G9a HMTase and generation of H3K9me2 in vitro. In its inhibition of the histone lysine methyltransferases, BIX-01294 does not compete with cofactor S-adenosyl-methionine. G9a HMTase regulates gene expression including one of the pluripotency genes Oct4. It is reported that BIX-01294 enhances reprogramming efficiency of neural progenitor cells to the same levels as when four transcription factors (Oct4, Klf4, Sox2 and c-Myc) were introduced to somatic cells for generation of induced pluripotent stem cells. BIX-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes. |
| 别名 | BIX 01294; BIX01294;2-(六氢-4-甲基-1H-1,4-二氮杂卓-1-基)-6,7-二甲氧基-N-(1-(苯基甲基)-4-哌啶基)-4-喹唑啉胺;;BIX 01294; BIX01294; 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-(1-(phenylmethyl)-4-piperidinyl)-4-quinazolinamine;1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one |
BIX-01294,G9a和G9a样蛋白组蛋白甲基转移酶抑制剂
BIX-01294 （订货以英文为准）
编号：B127141
CAS号：935693-62-2
分子式：C28H38N6O2
分子量：490.64
| 产品名称 | BIX-01294 |
| 中文名称 | BIX-01294,G9a和G9a样蛋白组蛋白甲基转移酶抑制剂 |
| CAS号 | 935693-62-2 |
| 分子式（M.F.） | C28H38N6O2 |
| 分子量（M.W.） | 490.64 |
| 储存条件 | -20°C储存 |
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