溶解性 | Soluble in chloroform (1 mg/ml), 1-methyl-2-pyrrolidnone (2 mg/mL at 75 °C), DMSO (1.33 mg/mL), and DMF (10 mg/mL at 75 °C). |
存贮条件 | 储存温度-20°C |
应用 | A dual PI3K and mTOR inhibitor |
产品介绍 | BEZ235 (NVP-BEZ235, Dactolisib) ATP竞争性的抑制PI3K和mTOR,对p110α/γ/δ/β和mTOR(p70S6K)均有抑制作用,IC50分别为4 nM/5 nM/7 nM/75 nM/6 nM,对ATR也有抑制作用,IC50为21 nM;但对Akt和PDK1抑制作用微弱。 |
备注 | BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM/5 nM/7 nM/75 nM/6 nM, respectively. Inhibits ATR with IC50 of 21 nM; shown to be poor inhibitory to |
生化机理 | BEZ235 is a PI 3-kinase (PI3K) tyrosine kinase inhibitor and shows dual PI3K/mTOR inhibition (IC50 = 4, 5, 7 and 75 nM for PI 3-Kα, -γ, -δ, and -β, respectively). BEZ235 showed high target specificity and demonstrated antiproliferative activity against tumor cell lines in animal models of cancer. BEZ235 is an mTOR Complex 1 and mTOR Complex 2 catalytic inhibitor. BEZ235 also inhibits ATR (IC50 = 21nM). |
别名 | 2-甲基-2-[4-[3-甲基-2-氧代-8-(喹啉-3-基)-2,3-二氢咪唑并[4,5-C]喹啉-1-基]苯基]丙腈;NVP-BEZ235, Dactolisib;PI3K抑制剂;2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile |
BEZ235,有效的PI3K和mTOR抑制剂
BEZ235 (订货以英文为准)
编号:B126286
CAS号:915019-65-7
分子式:C30H23N5O
分子量:469.54
产品名称 | BEZ235 |
中文名称 | BEZ235,有效的PI3K和mTOR抑制剂 |
CAS号 | 915019-65-7 |
分子式(M.F.) | C30H23N5O |
分子量(M.W.) | 469.54 |
储存条件 | -20°C储存 |
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