| 溶解性 | DMSO 98 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A selective PI3K inhibitor |
| 产品介绍 | PIK-294是一种高度选择性p110δ抑制剂，IC50为10 nM，作用于PI3Kα/β/γ效果分别低1000，49和16倍。 |
| 备注 | PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively. |
| 生化机理 | PIK-294 displays selectivity with respect to the inhibition of PI3K isoforms p110β, p110δ, and p110γ, however it is most selective for PI3Kδ (IC 50 = 490, 10, and 160 nM, respectively). PIK-294 exhibits low sensitivity to p110Yalpha; with an IC50 value of 10 μM. The m-phenol moiety of PIK-294 is able to penetrate the deep-affinity pocket of the ATP binding site, and thus increases in vitro inhibitory activity. |
| 别名 | 2-[[4-氨基-3-(3-羟基苯基)-1H-吡唑并[3,4-d]嘧啶-1-基]甲基]-5-甲基-3-(2-甲基苯基)-4(3H)-喹唑啉酮;2-[[4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone |
PIK-294
PIK-294 （订货以英文为准）
编号：P129553
CAS号：900185-02-6
分子式：C28H23N7O2
分子量：489.53
| 产品名称 | PIK-294 |
| 中文名称 | PIK-294 |
| CAS号 | 900185-02-6 |
| 分子式（M.F.） | C28H23N7O2 |
| 分子量（M.W.） | 489.53 |
| 储存条件 | -20°C储存 |
搜索质检报告(COA)
搜索MSDS
相关产品
党沛 
