| 溶解性 | DMSO 78 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM. |
| 生化机理 | PIK-93 is a PI4KIIIβ inhibitor (IC50 at 19 nM). PIK-93 is the first reported PI4-kinase inhibitor, which is able to inhibit PI4KIIIβ at low-nanomolar range. In addition, PIK-93 also inhibits potently PI3Kγ in vitro (IC50 at 16 nM). PIK-93 inhibits p110α, p110β, p110δwith IC50 of 0.039, 0.59, 0.12 μM. PIK-93 also displays the typical hydrogen bonding to the backbone amide of Val882, and additional ones to the backbone carbonyl of Val882 and between its sulphonamide and Asp964. |
| 别名 | N-[5-[4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methylthiazol-2-yl]acetamide;N-[5-[4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methylthiazol-2-yl]acetamide |
PIK-93,PI3-Kγ，PI3-Kα和PI4-KIIIβ抑制剂
PIK-93 （订货以英文为准）
编号：P126888
CAS号：593960-11-3
分子式：C14H16N3O4S2CL
分子量：389.88
| 产品名称 | PIK-93 |
| 中文名称 | PIK-93,PI3-Kγ，PI3-Kα和PI4-KIIIβ抑制剂 |
| CAS号 | 593960-11-3 |
| 分子式（M.F.） | C14H16N3O4S2CL |
| 分子量（M.W.） | 389.88 |
| 储存条件 | 避光;-20°C储存 |
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