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GW9662,PPARγ拮抗剂

GW9662 （订货以英文为准）

编号：G125880
CAS号：22978-25-2
分子式：C13H9CLN2O3
分子量：276.68
货号 品牌 包装 目录价 您的价格 库存 数量 购买
G125880-50mg 阿拉丁 50mg ¥51.90
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G125880-250mg 阿拉丁 250mg ¥65.90
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G125880-10mg 阿拉丁 10mg ¥31.90
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G125880-1g 阿拉丁 1g ¥171.90
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G125880-25g 阿拉丁 25g ¥1638.90
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G125880-5g 阿拉丁 5g ¥479.90
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产品名称 GW9662
中文名称 GW9662,PPARγ拮抗剂
CAS号 22978-25-2
MDL编码 MFCD01215270
分子式（M.F.） C13H9CLN2O3
分子量（M.W.） 276.68
储存条件 2-8°C储存
溶解性Soluble in DMSO (26 mg/ml), methanol, 100% ethanol (10 mg/ml), DMF (~35 mg/ml), and 1:2 DMF : PBS (PH=7.2) (~0.5 mg/ml). Insoluble in water.
存贮条件储存温度2-8°C
应用A selective, irreversible, and effective PPARγ antagonist that also acts as a FXR and PXR agonist.
产品介绍GW9662是一种选择性PPAR拮抗剂，作用于PPARγ，IC50为3.3 nM，作用于PPARγ比作用于PPARα和PPARδ选择性强100到1000倍。
备注GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγversus PPARα and PPARδ.
生化机理GW 9662 is a selective, irreversible, and effective peroxisome proliferator activated receptor-γ (PPARγ) antagonist. PPARγ research demonstrates that GW 9662 covalently modifies Cys(285) and does not affect transcription of full-length PPARα and PPARδ. GW 9662 has been shown to block Rosiglitazone mediated activation of PPARγ, and improve growth inhibition induced by Rosiglitazone in breast tumor cell research. Additionally, reports indicate that GW 9662 blocks the protective activity of lipopolysaccharide, LPS, and acts as an agonist for the farnesoid X receptor (FXR) and pregnane X receptor (PXR) nuclear receptors.
别名2-氯-5-硝基苯甲酰苯胺;2-氯-5-硝基-N-苯基苯酰胺;GW 9662;GW-9662;2-Chloro-5-nitro-N-phenylbenzamide
信号词Danger
危害声明H341-H350-H360FD
警示性声明P201-P281-P308 + P313
WGK德国3
搜索质检报告(COA)
搜索MSDS
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