| 溶解性 | DMSO 111 mg/mL Water 22 mg/mL Ethanol 111 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | SB-743921是第二代高活性KSP抑制剂，Ki为0.1 nM，对MKLP1，Kin2，Kif1A，Kif15，KHC，Kif4和CENP-E无亲和力。 |
| 生化机理 | SB-743921 is greater efficacy in vivo against P388 leukemia. SB-743921 has significant efficacy in a broad spectrum of tumor models differing from that of taxanes. SB-743921 is shown to have activity against advanced human tumor xenografts Colo205 (complete regressions), MCF-7, SK-MES, H69, OVCAR-3 (complete and partial regressions), and HT-29, MX-1, MDA-MB-231, A2780 (tumor growth delay). SB-743921 doesn't cause the neuropathy often associated with the tubulin agents. |
| 别名 | SB743921; SB 743921; N-(3-氨基丙基)-N-((1R)-1-(7-氯-4-氧代-3-(苯基甲基)-4H-1-苯并吡喃-2-基)-2-甲基丙基)-4-甲基苯甲酰胺盐酸盐;;SB743921; SB 743921；（R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylbenzamide hydrochloride |
SB743921,强力驱动蛋白纺锤体蛋白KIF11抑制剂
SB743921 （订货以英文为准）
编号：S127932
CAS号：940929-33-9
分子式：C31H34CL2N2O3
分子量：553.52
| 产品名称 | SB743921 |
| 中文名称 | SB743921,强力驱动蛋白纺锤体蛋白KIF11抑制剂 |
| CAS号 | 940929-33-9 |
| 分子式（M.F.） | C31H34CL2N2O3 |
| 分子量（M.W.） | 553.52 |
| 储存条件 | -20°C储存 |
| Reaxys-RN | 624220 |
| RTECS | AU7357560 |
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