| 溶解性 | DMSO 88 mg/mL Water <1 mg/mL Ethanol 5 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | BYL719 is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, and minimal effect on PI3Kβ/γ/δ. Phase 1/2. |
| 生化机理 | BYL-719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL-719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. |
| 别名 | 1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-;1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)- |
阿培利司
BYL719 （订货以英文为准）
编号：B127311
CAS号：1217486-61-7
分子式：C19H22F3N5O2S
分子量：441.47
| 产品名称 | BYL719 |
| 中文名称 | 阿培利司 |
| CAS号 | 1217486-61-7 |
| 分子式（M.F.） | C19H22F3N5O2S |
| 分子量（M.W.） | 441.47 |
| 储存条件 | -20°C储存 |
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