溶解性 | DMSO 104 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
存贮条件 | 储存温度-20°C |
备注 | BMS-708163 is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. |
生化机理 | BMS-708163 is a γ-secretase inhibitor (GSI) (IC50 =0.3 nM) |
别名 | (2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide;(2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide |
VULM 1457,γ分泌酶抑制剂
Avagacestat (订货以英文为准)
编号:B126453
CAS号:1146699-66-2
分子式:C20H17CLF4N4O4S
分子量:520.89
产品名称 | Avagacestat |
中文名称 | VULM 1457,γ分泌酶抑制剂 |
CAS号 | 1146699-66-2 |
分子式(M.F.) | C20H17CLF4N4O4S |
分子量(M.W.) | 520.89 |
储存条件 | -20°C储存 |
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