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克立咪唑

Clemizole （订货以英文为准）

编号：C125175
CAS号：442-52-4
分子式：C19H20N3CL
分子量：325.84
货号 品牌 包装 目录价 您的价格 库存 数量 购买
C125175-25mg 阿拉丁 25mg ¥1499.90
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C125175-5mg 阿拉丁 5mg ¥394.90
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C125175-100mg 阿拉丁 100mg ¥3949.90
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产品名称 Clemizole
中文名称 克立咪唑
CAS号 442-52-4
分子式（M.F.） C19H20N3CL
分子量（M.W.） 325.84
储存条件 -20°C储存
溶解性25°C: DMSO
存贮条件储存温度-20°C
产品介绍Clemizole是H1受体拮抗剂，还能抑制NS4B的RNA结合及HCV的复制。
生化机理Description:IC50 Value: 8mM (NS4B) [1]Clemizole is an H1 histamine receptor antagonist. Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.in vitro: Although significant, clemizole's antiviral effect is moderate (50% effective concentration of 8 microM against an HCV genotype 2a clone). Combinations of clemizole with either interferon, ribavirin, or the nucleoside (NM283) and nonnucleoside (HCV796) HCV polymerase inhibitors were additive [1]. The differences in the rodent and human pathways for clemizole metabolism were of importance, because the predominant human metabolite was found to have synergistic anti-HCV activity [2].in vivo: Clemizole and reserpine treatment did not produce any modification of the dose-response curve to histamine [3].Clinical trial: Safety and Tolerability Study of Clemizole Hydrochloride to Treat Hepatitis C in Subject
别名克立咪唑;1-(p-chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole; 1-p-chlorobenzyl-2-(1-pyrrolidinylmethyl)benzimidazole; 1-p-chlorobenzyl-2-pyrrolidino-methylbenzimidazole; depocural; histacur; histakool; lergopenin; nsc 46261
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